Applications

Preanalytical Urine Sample Solutions

Connect first-void urine collection and preservation with recovery-focused molecular sample preparation.

COLLECT First-Void Urine

PRESERVE At Collection

EXTRACT cfDNA + cfRNA

Applications cfDNA cfRNA | cfTNA Urine Preanalytical Urine CTC Exosomes Infectious Disease

APPLICATIONS Preanalytical Urine Sample Solutions

COLLECTION + PRESERVATION + EXTRACTION

Strong liquid biopsy workflows begin before extraction.

Preanalytical decisions influence the biological material presented to downstream molecular workflows. For urine liquid biopsy, that process begins with how the specimen is collected, preserved, transported, and prepared before extraction.

nRichDX and Novosanis, an OraSure Technologies company, have collaborated on a urine liquid biopsy workflow connecting first-void urine collection and preservation using Colli-Pee UAS™ with molecular sample preparation using the nRichDX Revolution platform.

The combined approach has been evaluated for controlled first-void urine collection, preservative compatibility, and downstream extraction of circulating nucleic acids from urine samples.

CONTROLLED COLLECTION

Defined starting point

Volumetric first-void urine collection helps standardize the specimen entering the workflow.

PRESERVATION

Stabilize at collection

UAS preservative is designed to stabilize molecular material in collected first-void urine.

MOLECULAR RECOVERY

Downstream extraction

Revolution sample preparation supports extraction of circulating nucleic acids from urine.

THE PREANALYTICAL WORKFLOW

A connected path from collection to extraction.

Standardized first-void urine collection, preservation, and downstream molecular extraction can be considered as one connected upstream workflow rather than independent steps.

THE WORKFLOW BEGINS AT COLLECTION Protect the molecular starting point before the specimen reaches the assay.

FIRST-VOID URINE Collect

AT COLLECTION Preserve

REVOLUTION SAMPLE PREP Extract

FIRST-VOID URINE COLLECTION

Standardize the specimen before it reaches the laboratory.

Colli-Pee™ is designed for volumetric collection of first-void urine.

Colli-Pee UAS™ configurations support non-invasive self-collection of a defined first-void urine volume together with preservative designed for molecular sample stabilization.

Paired with Revolution sample preparation, the workflow connects collection and preservation upstream with recovery-focused molecular extraction in the laboratory.

CONNECTED WORKFLOW Colli-Pee UAS™ collection + nRichDX Revolution sample preparation.

Colli-Pee UAS urine collection device and nRichDX Revolution sample preparation platform

Novosanis and nRichDX first-void urine application note

APPLICATION NOTE Collection · Preservation · Extraction

JOINT APPLICATION NOTE

First-void urine collection, preservation, and extraction.

The joint Novosanis/DNA Genotek and nRichDX application note evaluates collection, preservation, and extraction of cell-free DNA from first-void urine using Colli-Pee UAS™ and the Revolution Sample Prep System.

The study evaluated preservative compatibility, urine storage conditions, molecular recovery, and downstream detection as part of a connected preanalytical workflow.

View the Application Note

SCIENTIFIC EVIDENCE

Research spanning collection, preservation, extraction, and detection.

nRichDX and collaborators have evaluated urine liquid biopsy workflows across multiple analytes, sample volumes, collection approaches, and downstream molecular applications.

AMP 2022

Colli-Pee UAS + Revolution

Colli-Pee UAS Combined with nRichDX Revolution System, a Promising Urinary Cell-free DNA Collection, Preservation and Extraction Workflow.

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AACR 2024

First-Void Urine and Plasma

First-void urine as a non-invasive proxy for plasma in prostate cancer-related liquid biopsy applications.

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AMP 2024

cfRNA from 50 mL Urine

Enhanced Extraction and Preservation of Circulating Cell-Free RNA from 50 mL Cell-Free Urine.

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AACR 2024

Increasing Urine Input Volume

Enhancing urine-based cfDNA detection for prostate cancer diagnosis through increased input volume.

View Poster

COLLABORATION

A preanalytical urine workflow built across the specimen journey.

Hear more about the nRichDX and Novosanis collaboration and the combined approach to first-void urine collection, preservation, and molecular sample preparation.

URINE LIQUID BIOPSY RESOURCES

Go deeper into the preanalytical urine workflow.

Explore application data, posters, publications, and technical resources spanning first-void urine collection, preservation, high-volume extraction, cfDNA, cfRNA, and downstream analysis.

Collection & Preservation Urine Extraction Posters & Publications

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